Shrizine Injection Overdosage

Symptoms: Difficulty in breathing due to spasm of the respiratory muscles and other severe extra pyramidal side effects.
Treatment is essentially symptomatic and supportive.
Do not attempt to induce emesis because a dystonic reaction of head and neck may develop that could result in aspiration of vomitus.
Early stomach lavage is often helpful.
Administering activated charcoal slurry and saline cathartic.
Maintaining respiratory functions and body temperature.
Monitoring cardiovascular function (monitor cardiac function for not less than 5 days).
Controlling cardiac arrhythmias with intravenous phenytoin, 9 to 11 mg / kg.
Digitalizing for cardiac failure.
Administering vasopressor such as norepinephrine for hypotension (do not use epinephrine, which may cause paradoxical hypotension).
Controlling convulsions with diazepam followed by phenytoin, 15 mg/kg, while monitoring ECG.
Benztropine or diphenhydramine may be administered to manage acute, parkinson-like symptoms may occur.
Severe CNS depression may require administration of a stimulant such as amphetamine, dextroamphetamine, or caffeine with sodium benzoate (picrotoxin or penthylene-tetrazol) should be avoided as they may induce convulsions.
Dialysis of phenothiazines has not been successful.